蔡 磊 博士,副研究员,2006年毕业于浙江大学,2014年于中国科学院微生物研究所获得博士学位,同年加入bepaly体育,主要致力于1)人工甜味剂与甜味受体的互作关系研究;2)人工甜味剂与肠道微生物;3)高盐食品微生物资源开发利用;
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近年研究项目情况:
1、浙江省省属高校基本科研业务费项目,重点项目,人工甜味剂三氯蔗糖ADI范围长期暴露的肠道作用靶点及其生理影响研究,2021/10-2024/10,在研,主持;
2、国家自然科学基金委员会,面上项目,基于核糖体开关的维生素B12对肠道菌群及其代谢调
控机制研究, 2021/01 至 2024/12,在研,参与(2/8);
3、国家自然科学基金委员会,青年项目,31701602,人工甜味剂饮食暴露诱发餐后血糖异常升高的机制研究,2018/01-2020/12,结题,主持;
4、浙江省科技计划项目(公益),2017C33040,市售人工甜味剂ADI范围内长期摄入诱发机体葡萄糖代谢异常的风险研究,2017/01-2018/12,结题,主持;
已发表论文(通讯或第一):
1. Long term exposure to sucralose alters
the sense of sweet tastants in an intestinal enteroendocrine cell model. International Food Research Journal,
2022.
2. Production of Polyhydroxyalkanoates in
Unsterilized Hyper-Saline Medium by Halophiles Using Waste Silkworm Excrement
as Carbon Source. Molecules, 2021.
3. Nitrogen Removal Performance and
Metabolic Pathways Analysis of a Novel Aerobic Denitrifying Halotolerant Pseudomonas
balearica Strain RAD-17. Microorganisms, 2020.
4. Low intake of digestible carbohydrates
ameliorates duodenal absorption of carbohydrates in mice with glucose
metabolism disorders induced by artificial sweeteners[J]. 2019.
5. Comparisons
of Effects on Intestinal Short-Chain Fatty Acid Concentration after Exposure of
Two Glycosidase Inhibitors in Mice, 2018.
6. Analysis of the transcriptional regulator
GlpR, promoter elements, and posttranscriptional processing involved in
fructose-induced activation of the phosphoenolpyruvate-dependent sugar
phosphotransferase system in Haloferax mediterranei. Appl Environ Microbiol, 2014.
7. Cellular and organellar
membrane-associated proteins in haloarchaea: perspectives on the physiological
significance and biotechnological applications. Sci China Life Sci, 2012.