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Caroline Orfila
( 发布日期:2020/11/20 阅读:次)

Employment history

University of Leeds, UK:

2020-           Professor of Nutrition

2012-2019   Associate Professor of Nutrition (grade 9)

2009-2012    Lecturer in Nutrition (grade 8)

Roles and responsibilities

2018-           Associate Director of the Global Food and Environment Institute

2016-           Research Excellence Framework leader, Agriculture, Food and Veterinary Science UoA6

2016-           Line Manager to 2 academic staff, 3 administrative staff, 2 postdoctoral researchers

2014-           Member of School Management Group

2016-           Member of the N8 (Northern Universities) Agrifood Working Group

2014-2019   Director of Research and Innovation

2009-2016   Research Group Leader

2014-2017   Athena Swan academic lead

2017-2018   Member of the University GCRF advisory group

2015-2019   Chair of the Industry Advisory Board for Food Research and Innovation

2012-2019   Member of the Faculty Ethics Committee

2012-2017   Programme Leader MSc and BSc Nutrition

2010-2013   Admissions Tutor

University of Northumbria, UK:

2004-2008   Senior Lecturer in Food Science and Nutrition

2005-2006   Postgraduate Diploma in Academic Practice (PCAP)

2004-2005   NEBOSHH diploma (with merit)

Royal Agricultural and Veterinary University, Copenhagen, Denmark:

2001-2004   Postdoctoral Fellow in Plant Biochemistry (Europectin EU project)


1997-2001   PhD studentship, BBSRC CASE award in Plant Science, University of Leeds, UK

1994-1997   BSc (Hons) Biochemistry and Food Science, First Class, University of Leeds, UK

2001-           Prize for best performance in Combined Science

1996-1997   AgroBiosup, Agricultural Engineering, Dijon France

1994-1996   International Baccalaureate (39/42), ATC International School, Hilversum, the Netherlands

Professional memberships

Since 2006   Fellow of the Higher Education Academy (FHEA)

Since 2010   Registered Nutritionist (Association for Nutrition)

Language proficiency

Fluent: English, French and Spanish

Basic knowledge: Dutch, Danish and Italian

Research vision

      The aim of my research is to enhance the dietary health of people across the world by improving the nutritional profile of processed foods. The focus is on understanding pre- and post-harvest processing effects on nutritional quality and safety of a range of plant crops, including legume and cereal seeds, tubers, fruits and vegetables. Low cost and efficient agricultural and food processing methods can be used to reduce waste, extend shelf life and enhance the nutritional quality diets. A major focus is the study of food carbohydrates (cell wall polysaccharides (i.e. fibre), starch, sugar), and the impact of processing on their properties.

Peer reviewed publications (Scopus H-Index 19)

1. Scharf, R., Wang, R., Maycock, J., Ho, P., Chen, S., & Orfila, C. (2019). Valorisation of Potato (Solanum tuberosum) Peel Waste: Extraction of Fibre, Monosaccharides and Uronic Acids. Waste and Biomass Valorization. doi:10.1007/s12649-018-0532-2

2. Bordoni, A., Bosch, C., Malpuech-Brugere, C., Orfila, C., & Tomas-Cobos, L. (2019). The role of bioactives in energy metabolism and metabolic syndrome. Proceedings of the Nutrition Society. In Press

3. Allen, B., & Orfila, C. (2018). The availability and nutritional adequacy of gluten-free bread and pasta. Nutrients, 10(10). doi:10.3390/nu10101370

4. Rabiti, D., Orfila, C., Holmes, M., Bordoni, A., & Sarkar, A. (2018). In vitro  oral processing of raw tomato: Novel insights into the role of endogenous fruit enzymes. Journal of Texture Studies, 49(4), 351-358. doi:10.1111/jtxs.12338

5. Zhang, H., Chen, J., Li, J., Yan, L., Li, S., Ye, X., Orfila C., Linhardt R., Chen, S. (2018). Extraction and characterization of RG-I enriched pectic polysaccharides from mandarin citrus peel. Food Hydrocolloids, 79, 579-586. doi:10.1016/j.foodhyd.2017.12.002

6. Li, J., Li, S., Zheng, Y., Zhang, H., Chen, J., Yan, L., Orfila C., Linhardt R., Chen, S. (2018). ssFast preparation of rhamnogalacturonan I enriched low molecular weight pectic polysaccharide by ultrasonically accelerated metal-free Fenton reaction. Food Hydrocolloids. doi:10.1016/j.foodhyd.2018.05.025

7. Phongnarisorn, B., Orfila, C., Holmes, M., & Marshall, L. J. (2018). Enrichment of Biscuits with Matcha Green Tea Powder: Its Impact on Consumer Acceptability and Acute Metabolic Response. Foods, 7(2). doi:10.3390/foods7020017

8. Karim, Z., Holmes, M., & Orfila, C. (2017). Inhibitory effect of chlorogenic acid on digestion of potato starch. Food Chemistry, 217, 498-504. doi:10.1016/j.foodchem.2016.08.058

9. Chu, J., Igbetar, B. D., & Orfila, C. (2017). Fibrous Cellular Structures are Found in a Commercial Fruit Smoothie and Remain Intact during Simulated Digestion. Journal of Nutrition and Food Sciences, 7(1). doi:10.4172/2155-9600.1000576

10. Bolarinwa, I. F., Orfila, C., & Morgan, M. R. A. (2015). Determination of amygdalin in apple seeds, fresh apples and processed apple juices. Food Chemistry, 170, 437-442. doi:10.1016/j.foodchem.2014.08.083

11. Alwariji. M., Orfila, C., Chu, J., & Burley, V. (2014). Analysis of dietary fibre of boiled and canned legumes commonly

consumed in the United Kingdom. Journal of Food Composition and Analysis, 36(1-2), 111-116. doi:10.1016/j.jfca.2014.06.010

12. Bolarinwa, I. F., Orfila, C., & Morgan, M. R. A. (2014). Development and application of an enzyme-linked immunosorbent assay (ELISA) for the quantification of amygdalin, a cyanogenic glycoside, in food. Journal of Agricultural and Food Chemistry, 62(27), 6299-6305. doi:10.1021/jf501978d

13. Bolarinwa, I. F., Orfila, C., & Morgan, M. R. A. (2014). Amygdalin content of seeds, kernels and food products commercially- available in the UK. Food Chemistry, 152, 133-139. doi:10.1016/j.foodchem.2013.11.002

14. Wong, C. C., Akiyama, Y., Abe, T., Lippiat, J. D., Orfila, C., & Williamson, G. (2012). Carrier-mediated transport of quercetin conjugates: Involvement of organic anion transporters and organic anion transporting polypeptides. Biochemical Pharmacology, 84(4), 564-570. doi:10.1016/j.bcp.2012.05.011

15. Orfila, C., Degan, F. D., Jørgensen, B., Scheller, H. V., Ulvskov, P., Scheller, H. V., Jørgensen, B. (2012). Expression of mung bean pectin acetyl esterase in potato tubers: effect on acetylation of cell wall polymers and tuber mechanical properties. Planta, 1-12. doi:

16. Atkinson, N. J., Dew, T. P., Orfila, C., & Urwin, P. E. (2011). Influence of Combined Biotic and Abiotic Stress on Nutritional Quality Parameters in Tomato ( Solanum lycopersicum ). Journal of Agricultural and Food Chemistry, 59(17), 9673-9682. doi:10.1021/jf202081t

17. Black, J. L., & Orfila, C. (2011). Impact of coeliac disease on dietary habits and quality of life. Journal of Human Nutrition and Dietetics, 24(6), 582-587. doi:10.1111/j.1365-277X.2011.01170.x

18. Wong, C. C., Barron, D., Orfila, C., Dionisi, F., Krajcsi, P., & Williamson, G. (2011). Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters. Molecular Nutrition & Food Research, 55(7), 979-988. doi:10.1002/mnfr.201000652

19. Wong, C. C., Botting, N. P., Orfila, C., Al-Maharik, N., & Williamson, G. (2011). Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6). Biochemical Pharmacology, 81(7), 942-949. doi:10.1016/j.bcp.2011.01.004

20. Manabe, Y., Nafisi, M., Verhertbruggen, Y., Orfila, C., Gille, S., Rautengarten, C., . . . Pauly, M. (2011). Loss-of-Function Mutation of REDUCED WALL ACETYLATION2 in Arabidopsis Leads to Reduced Cell Wall Acetylation and Increased Resistance to Botrytis cinerea. PLANT PHYSIOLOGY, 155(3), 1068-1078. doi:10.1104/pp.110.168989

21. Atkinson, N. J., Orfila, C., & Urwin, P. E. (2010). Investigating the response of Arabidopsis thaliana and Solanum lycopersicum to multiple simultaneous stresses. Proceedings of the Nutrition Society, 69(OCE4). doi:10.1017/S0029665110001369

22. Harholt, J. (2005). ARABINAN DEFICIENT 1 Is a Putative Arabinosyltransferase Involved in Biosynthesis of Pectic Arabinan in Arabidopsis. PLANT PHYSIOLOGY, 140(1), 49-58. doi:10.1104/pp.105.072744

23. Orfila, C., Sorensen, S. O., Harholt, J., Geshi, N., Crombie, H., Truong, H. N., . . . Scheller, H. V. (2005). QUASIMODO1 is expressed in vascular tissue of Arabidopsis thaliana inflorescence stems, and affects homogalacturonan and xylan biosynthesis . Planta, 222(4), 613-622. doi:10.1007/s00425-005-0008-z

24. Manfield, I. W., Orfila, C., McCartney, L., Harholt, J., Bernal, A. J., Scheller, H. V., . . . Willats, W. G. T. (2004). Novel cell wall architecture of isoxaben-habituated Arabidopsis suspension-cultured cells: global transcript profiling and cellular analysis. The Plant Journal, 40(2), 260-275. doi:10.1111/j.1365-313X.2004.02208.x

25. Øbro, J., Harholt, J., Scheller, H. V., & Orfila, C. (2004). Rhamnogalacturonan I in Solanum tuberosum tubers contains complex arabinogalactan structures. Phytochemistry, 65(10), 1429-1438. doi:10.1016/j.phytochem.2004.05.002

26. Orfila, C., Huisman, M. M. H., Willats, W. G. T., van Alebeek, G., Schols, H. A., Seymour, G. B., & Knox, J. P. (2002). Altered cell wall disassembly during ripening of Cnr tomato fruit: Implications for cell adhesion and fruit softening. Planta, 215(3), 440-447. doi:10.1007/s00425-002-0753-1

27. Orfila, C., Seymour, G. B., Willats, W. G. T., Huxham, I. M., Jarvis, M. C., Dover, C. J., . . . Knox, J. P. (2001). Altered middle lamella homogalacturonan and disrupted deposition of (1-->5)-alpha-l-arabinan in the pericarp of cnr, a ripening mutant of tomato. Plant Physiology, 126(1), 210-221. doi:10.1104/pp.126.1.210

28. Willats, W. G. T., Orfila, C., Limberg, G., Buchholt, H. C., van Alebeek, G., Voragen, A. G. J., . . . Knox, J. P. (2001). Modulation of the degree and pattern of methyl-esterification of pectic homogalacturonan in plant cell walls - Implications for pectin methyl esterase action, matrix properties, and cell adhesion. Journal of Biological Chemistry, 276, 19404-19413. doi:10.1074/jbc.M011242200

29. Knox, J. P., & Orfila, C. (2000). Spatial regulation of pectic polysaccharides in relation to pit fields in cell walls of tomato fruit pericarp. Plant Physiology, 122, 775-781.

30. Williats, W. G. T., Steele-King, C. G., McCartney, L., Orfila, C., Marcus, S. E., & Knox, J. P. (2000). Making and using antibody probes to study plant cell walls. Plant Physiology and Biochemistry, 38, 27-36.

31. Thompson, A. J., Tor, M., Barry, C. S., Vrebalov, J., Orfila, C., Jarvis, M. C., Seymour, G. B. (1999). Molecular and genetic characterization of a novel pleiotropic tomato-ripening mutant. Plant Physiology, 120(2), 383-389.

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